RBPJ antibody (AA 243-485) (HRP)

Catalog No. ABIN7167537

The Rabbit Polyclonal anti-RBPJ antibody is suitable to detect RBPJ in samples from Human. It has been validated for ELISA.

Quick Overview for RBPJ antibody (AA 243-485) (HRP) (ABIN7167537)

Target: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBPJ antibody is conjugated to HRP

Application: ELISA

Product Details anti-RBPJ Antibody (HRP)

Binding Specificity: AA 243-485

Purpose: RBPJ Antibody, HRP conjugated

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Recombining binding protein suppressor of hairless protein (243-485AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RBPJ

Target: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Alternative Name: RBPJ

Background:

Background: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4 % oxygen) (PubMed:23303788).

Aliases: AI843960 antibody, AOS3 antibody, CBF 1 antibody, CBF-1 antibody, CBF1 antibody, csl antibody, IGKJRB antibody, IGKJRB1 antibody, J kappa recombination signal binding protein antibody, J kappa-recombination signal-binding protein antibody, KBF2 antibody, NY REN 30 antigen antibody, RBP J antibody, RBP J kappa antibody, RBP JK antibody, RBP-J antibody, RBP-J kappa antibody, RBP-JK antibody, Rbpj antibody, RBPJK antibody, RBPSUH antibody, recombination signal binding protein for immunoglobulin kappa J region antibody, Recombining binding protein suppressor of hairless antibody, Renal carcinoma antigen NY-REN-30 antibody, SUH antibody, SUH_HUMAN antibody

UniProt: Q06330

Pathways: Notch Signaling, Stem Cell Maintenance, Smooth Muscle Cell Migration