p130 antibody (AA 417-616) (Biotin)

Catalog No. ABIN7167792

The Rabbit Polyclonal anti-p130 antibody has been validated for ELISA. It is suitable to detect p130 in samples from Human.

Quick Overview for p130 antibody (AA 417-616) (Biotin) (ABIN7167792)

Target: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This p130 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-p130 Antibody (Biotin)

Binding Specificity: AA 417-616

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Retinoblastoma-like protein 2 protein (417-616AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for p130

Target: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Alternative Name: RBL2

Background:

Background: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 \'Lys-20\' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Aliases: 130 kDa retinoblastoma associated protein antibody, 130 kDa retinoblastoma-associated protein antibody, IB4 antibody, p130 antibody, PPAR-alpha-interacting complex protein 128 antibody, PRB2 antibody, Rb2 antibody, Rbl2 antibody, RBL2_HUMAN antibody, RBR 2 antibody, RBR-2 antibody, RBR2 antibody, Retinoblastoma like 2 antibody, Retinoblastoma-like protein 2 antibody, Retinoblastoma-related protein 2 antibody, RIC128 antibody

UniProt: Q08999

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases