SMARCC2 antibody (AA 300-650)

Catalog No. ABIN7171057

Product Details anti-SMARCC2 Antibody

Target: SMARCC2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily C, Member 2 (SMARCC2))

Binding Specificity: AA 300-650

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMARCC2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human SWI/SNF complex subunit SMARCC2 protein (300-650AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SMARCC2

Target: SMARCC2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily C, Member 2 (SMARCC2))

Alternative Name: SMARCC2 (SMARCC2 Products)

Synonyms: MGC80068 antibody, BAF170 antibody, CRACC2 antibody, Rsc8 antibody, 5930405J04Rik antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 L homeolog antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 antibody, smarcc2.L antibody, SMARCC2 antibody, smarcc2 antibody, Smarcc2 antibody

Background:

Background: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth

Aliases: BAF 170 antibody, BAF170 antibody, BRG1 associated factor 170 antibody, BRG1-associated factor 170 antibody, Chromatin remodeling complex BAF170 subunit antibody, CRACC 2 antibody, CRACC2 antibody, Mammalian chromatin remodeling complex BRG1 associated factor 170 antibody, Rsc 8 antibody, Rsc8 antibody, SMARCC 2 antibody, Smarcc2 antibody, SMRC2_HUMAN antibody, SWI/SNF complex 170 kDa subunit antibody, SWI/SNF complex subunit SMARCC2 antibody, SWI/SNF related matrix associated actin dependent regulator of chromatin c2 antibody, SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 2 antibody, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 antibody, SWI3 like protein antibody

UniProt: Q8TAQ2