TARDBP antibody (AA 1-396) (HRP)

Catalog No. ABIN7171512

The Rabbit Polyclonal anti-TARDBP antibody has been validated for ELISA. It is suitable to detect TARDBP in samples from Human.

Quick Overview for TARDBP antibody (AA 1-396) (HRP) (ABIN7171512)

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TARDBP antibody is conjugated to HRP

Application: ELISA

Product Details anti-TARDBP Antibody (HRP)

Binding Specificity: AA 1-396

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human TAR DNA-binding protein 43 protein (1-396AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Alternative Name: TARDBP

Background:

Background: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.

Aliases: ALS10 antibody, OTTHUMP00000002171 antibody, OTTHUMP00000002172 antibody, OTTHUMP00000002173 antibody, TADBP_HUMAN antibody, TAR DNA binding protein 43 antibody, TAR DNA binding protein antibody, TAR DNA-binding protein 43 antibody, TARDBP antibody, TDP 43 antibody, TDP-43 antibody, TDP43 antibody

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion