DIO3 antibody (AA 50-115) (Biotin)

Catalog No. ABIN7172189

This Rabbit Polyclonal antibody specifically detects DIO3 in ELISA. It exhibits reactivity toward Human.

Quick Overview for DIO3 antibody (AA 50-115) (Biotin) (ABIN7172189)

Target: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DIO3 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-DIO3 Antibody (Biotin)

Binding Specificity: AA 50-115

Purpose: DIO3 Antibody, Biotin conjugated

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Thyroxine 5-deiodinase protein (50-115AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DIO3

Target: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Alternative Name: DIO3

Background:

Background: Responsible for the deiodination of T4 (3,5,3\',5\'-tetraiodothyronine) into RT3 (3,3\',5\'-triiodothyronine) and of T3 (3,5,3\'-triiodothyronine) into T2 (3,3\'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.

Aliases: 5DIII antibody, D3 antibody, Deiodinase iodothyronine type 3 antibody, Deiodinase iodothyronine type III antibody, Dio 3 antibody, Dio3 antibody, DIOIII antibody, IOD3_HUMAN antibody, Iodothyronine deiodinase placental type antibody, MGC124117 antibody, MGC124118 antibody, Thyroxine deiodinase type III antibody, Thyroxine deiodinase type III (selenoprotein) antibody, TXDI3 antibody, Type 3 DI antibody, Type 3 iodothyronine selenodeiodinase antibody, Type III 5' deiodinase antibody, Type III iodothyronine deiodinase antibody, Type-III 5''-deiodinase antibody

UniProt: P55073

Pathways: Hormone Activity