Myosin VIIA antibody (AA 838-968)

Catalog No. ABIN7174961

This Rabbit Polyclonal antibody specifically detects Myosin VIIA in ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for Myosin VIIA antibody (AA 838-968) (ABIN7174961)

Target: Myosin VIIA (MYO7A)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Myosin VIIA antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Myosin VIIA Antibody

Binding Specificity: AA 838-968

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Unconventional myosin-VIIa protein (838-968AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Myosin VIIA

Target: Myosin VIIA (MYO7A)

Alternative Name: MYO7A

Background:

Background: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.

Aliases: MYO7A antibody, USH1B antibody, Unconventional myosin-VIIa antibody

UniProt: Q13402

Pathways: Sensory Perception of Sound