VPS33A antibody (AA 1-300) (Biotin)

Catalog No. ABIN7175309

Product Details anti-VPS33A Antibody (Biotin)

Target: VPS33A (Vacuolar Protein Sorting 33 Homolog A (VPS33A))

Binding Specificity: AA 1-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VPS33A antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Vacuolar protein sorting-associated protein 33A protein (1-300AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for VPS33A

Target: VPS33A (Vacuolar Protein Sorting 33 Homolog A (VPS33A))

Alternative Name: VPS33A (VPS33A Products)

Synonyms: r-Vps33a antibody, VPS33A antibody, vps33a antibody, MGC145524 antibody, 3830421M04Rik antibody, AI503300 antibody, AW048546 antibody, AW554476 antibody, bf antibody, im:7136893 antibody, wu:fc08g01 antibody, wu:fc26c10 antibody, VPS33A CORVET/HOPS core subunit antibody, VPS33A, CORVET/HOPS core subunit antibody, vacuolar protein sorting 33 homolog A (S. cerevisiae) antibody, Vacuolar protein sorting 33A antibody, VPS33A, CORVET/HOPS core subunit L homeolog antibody, vacuolar protein sorting 33A antibody, Vps33a antibody, VPS33A antibody, vps33a antibody, CGB_E2330C antibody, vps33a.L antibody

Background:

Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes, the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).

Aliases: VPS33AVacuolar protein sorting-associated protein 33A antibody, hVPS33A antibody

UniProt: Q96AX1