WEE1 antibody (AA 45-177)

Catalog No. ABIN7175814

The Rabbit Polyclonal anti-WEE1 antibody has been validated for ELISA. It is suitable to detect WEE1 in samples from Human.

Quick Overview for WEE1 antibody (AA 45-177) (ABIN7175814)

Target: WEE1 (WEE1 Homolog (S. Pombe) (WEE1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WEE1 antibody is un-conjugated

Application: ELISA

Product Details anti-WEE1 Antibody

Binding Specificity: AA 45-177

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Wee1-like protein kinase protein (45-177AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for WEE1

Target: WEE1 (WEE1 Homolog (S. Pombe) (WEE1))

Alternative Name: WEE1

Background:

Background: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on \'Tyr-15\'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on \'Tyr-15\' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.

Aliases: DKFZp686I18166 antibody, EC 2.7.10.2 antibody, FLJ16446 antibody, MGC105683 antibody, OTTHUMP00000231338 antibody, OTTHUMP00000231339 antibody, Wee 1 antibody, WEE 1 homolog 1 (S. pombe) antibody, WEE1 antibody, WEE1 homolog (S. pombe) antibody, Wee1 homolog antibody, WEE1 homolog S. pombe antibody, Wee1 like protein kinase antibody, Wee1 tyrosine kinase antibody, Wee1+ homolog antibody, Wee1+ S. pombe homolog antibody, WEE1, S. pombe, homolog of antibody, WEE1, somatic antibody, Wee1-like protein kinase antibody, WEE1_HUMAN antibody, WEE1A antibody, Wee1A kinase antibody, WEE1hu antibody

UniProt: P30291

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases, M Phase