FHIT antibody (AA 2-150) (Biotin)

Catalog No. ABIN7177010

This Rabbit Polyclonal antibody specifically detects FHIT in ELISA. It exhibits reactivity toward Mouse.

Quick Overview for FHIT antibody (AA 2-150) (Biotin) (ABIN7177010)

Target: FHIT (Fragile Histidine Triad (FHIT))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FHIT antibody is conjugated to Biotin

Application: ELISA

Product Details anti-FHIT Antibody (Biotin)

Binding Specificity: AA 2-150

Cross-Reactivity: Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Mouse Bis(5\\\'-adenosyl)-triphosphatase protein (2-150AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FHIT

Target: FHIT (Fragile Histidine Triad (FHIT))

Alternative Name: Fhit

Background:

Background: Cleaves P(1)-P(3)-bis(5\\\'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5\\\'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5\\\'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity). Functions as tumor suppressor.

Aliases: FhitBis(5'-adenosyl)-triphosphatase antibody, EC 3.6.1.29 antibody, AP3A hydrolase antibody, AP3Aase antibody, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase antibody, Dinucleosidetriphosphatase antibody, Fragile histidine triad protein antibody

UniProt: O89106