CD45 antibody (PE-Cy5)

Catalog No. ABIN7178551

The PE-Cy5-conjugated Mouse Monoclonal anti-CD45 antibody (ABIN7178551) specifically detects CD45 in FACS, IF and ELISA. The antibody is reactive with Human samples.

Quick Overview for CD45 antibody (PE-Cy5) (ABIN7178551)

Target: CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD45 antibody is conjugated to PE-Cy5

Application: Flow Cytometry (FACS), Immunofluorescence (IF), ELISA

Product Details anti-CD45 Antibody (PE-Cy5)

Purpose: PTPRC Monoclonal Antibody,PE-Cy5 Conjugated

Purification: Affinity purified

Immunogen: Recombinant Protein

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered solution, pH 7.4, containing 0.09 % sodium azide and 0.2 % (w/v) BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CD45

Target: CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))

Alternative Name: PTPRC

Background:

Background: 4AA9 reacts with CD45, a 180-220 kDa leukocyte common antigen (LCA). CD45 antigen is expressed at high levels on all hematopoietic cells including T and B lymphocytes, monocytes, granulocytes, NK cells and dendritic cells, but is not expressed on non-hematopoietic cells. CD45 antibody has also been reported to react weakly with mature blood erythrocytes and platelets. CD45 is a protein tyrosine phosphatase receptor that is critically important for T and B cell antigen receptor-mediated activation.*Target of immunosuppresive antibody treatment.1. Knapp, W et al., eds. (1989)  Leucocyte Typing  IV: White Cell Differentiation Antigens, Oxford University Press, New York.2. Trowbridge, IS and Thomas, ML. (1993) Annu. Rev. Immunol. 12:85.3. Pulido, R et al., (1988) J. Immunol.  140:3851.4. Roach, T et al., (1997) Curr. Biol. 7:408.

Aliases: N/A

UniProt: P08575

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling