TNF alpha antibody (AA 78-234)

Catalog No. ABIN7179334

This anti-TNF alpha antibody is a Rabbit Polyclonal antibody detecting TNF alpha in WB and ELISA. Suitable for Sheep.

Quick Overview for TNF alpha antibody (AA 78-234) (ABIN7179334)

Target: TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))

Reactivity: Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNF alpha antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TNF alpha Antibody

Binding Specificity: AA 78-234

Purpose: TNF Antibody

Cross-Reactivity: Sheep

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Sheep Tumor necrosis factor protein (78-234AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TNF alpha

Target: TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))

Alternative Name: TNF

Background:

Background: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells

Aliases: TNF antibody, TNFA antibody, TNFSF2 antibody, Tumor necrosis factor antibody, Cachectin antibody, TNF-alpha antibody, Tumor necrosis factor ligand superfamily member 2 antibody, TNF-a) [Cleaved into: Tumor necrosis factor antibody, membrane form antibody, N-terminal fragment antibody, NTF), Intracellular domain 1 antibody, ICD1), Intracellular domain 2 antibody, ICD2), C-domain 1, C-domain 2, Tumor necrosis factor antibody, soluble form] antibody

UniProt: P23383

Pathways: NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, TLR Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Inflammasome