H2AFX antibody (AA 130-142)
Quick Overview for H2AFX antibody (AA 130-142) (ABIN7181497)
Target
See all H2AFX AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 130-142
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Purpose
- H2AFX (Ab-142) Antibody
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Purification
- Antigen Affinity Purified
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Immunogen
- Synthesized peptide derived from Human Histone H2AX protein (130-142aa)
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Isotype
- IgG
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anti-H2A Histone Family, Member X (H2AFX) (AA 115-143), (C-Term) antibody
H2AFX Reactivity: Human WB, IHC (p) Host: Mouse Monoclonal 938CT5-1-1 unconjugated
anti-H2A Histone Family, Member X (H2AFX) (H2AXS139ph) antibodyH2AFX Reactivity: Human WB, ELISA, IF, ChIP Host: Rabbit Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) (ubLys119) antibodyH2AFX Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), ICC, IF (p), IF (cc), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) (pSer140) antibodyH2AFX Reactivity: Human WB, ELISA, IHC (p), ICC, FACS, IF (p), IF (cc), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) (H2A.XS139ph) antibodyH2AFX Reactivity: Human WB, ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) (AA 1-30), (N-Term) antibodyH2AFX Reactivity: Human WB, IHC (p) Host: Mouse Monoclonal 980CT1-5-5 unconjugated
anti-H2A Histone Family, Member X (H2AFX) antibodyH2AFX Reactivity: Human WB, IHC (p) Host: Mouse Monoclonal 8C5 unconjugated
anti-H2A Histone Family, Member X (H2AFX) (pSer139) antibodyH2AFX Reactivity: Human WB, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) (C-Term) antibodyH2AFX Reactivity: Human WB, IF, ICC, ChIP Host: Rabbit Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) (AA 12-141) antibodyH2AFX Reactivity: Human IHC, ELISA Host: Rabbit Polyclonal unconjugated
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- H2AFX (H2A Histone Family, Member X (H2AFX))
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Alternative Name
- H2AFX
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Background
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Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Aliases: Histone H2AX (H2a/x) (Histone H2A.X), H2AFX, H2AX
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UniProt
- P16104
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Pathways
- Telomere Maintenance, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
Target
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