EP3/CREBBP antibody
-
- Target
- EP3/CREBBP
- Reactivity
- Human
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogen
- Synthesized peptide derived from Human P300/CBP.
- Isotype
- IgG
-
- Application Notes
- WB:1:500-1:3000, IHC:1:50-1:100,
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- Target
- EP3/CREBBP
- Background
-
Background: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.
Gerd A. Blobel, J. Leukoc. Biol., Apr 2002, 71: 545.
Eric Kalkhoven, Hum. Mol. Genet., Feb 2003, 12: 441 - 450.
Wei-fang Shen, Mol. Cell. Biol., Nov 2001, 21: 7509 - 7522.
Frederick C. Nucifora, Science, Mar 2001, 291: 2423.Aliases: E1A associated protein p300 antibody, E1A binding protein p300 antibody, E1A-associated protein p300 antibody, EP300 antibody, EP300: E1A binding protein p300 antibody, EP300_HUMAN antibody, Histone acetyltransferase p300 antibody, KAT3B antibody, p300 HAT antibody, RSTS2 antibody
- UniProt
- Q09472
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