SCN4A antibody

Catalog No. ABIN7184120

Product Details anti-SCN4A Antibody

Target: SCN4A (Sodium Channel, Voltage-Gated, Type IV, alpha Subunit (SCN4A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCN4A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of Human SCN4A.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SCN4A

Target: SCN4A (Sodium Channel, Voltage-Gated, Type IV, alpha Subunit (SCN4A))

Alternative Name: SCN4A (SCN4A Products)

Synonyms: Nav1.4 antibody, SkM1 antibody, mH2 antibody, HOKPP2 antibody, HYKPP antibody, HYPP antibody, NAC1A antibody, Na(V)1.4 antibody, NCHVS antibody, microI antibody, Nav1.4b antibody, sodium channel, voltage-gated, type IV, alpha antibody, sodium voltage-gated channel alpha subunit 4 antibody, sodium channel, voltage-gated, type IV, alpha, b antibody, Scn4a antibody, SCN4A antibody, scn4ab antibody

Background:

Background: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.

George A.L. Jr., Ann. Neurol. 31:131-137(1992).
Wang J., Biochem. Biophys. Res. Commun. 182:794-801(1992).
Tsujino A., Proc. Natl. Acad. Sci. U.S.A. 100:7377-7382(2003).

Aliases: HYKPP antibody, HYPP antibody, Na(V)1.4 antibody, NAC1A antibody, Nav1.4 antibody, Scn4a antibody, SCN4A_HUMAN antibody, Skeletal muscle voltage dependent sodium channel type IV alpha subunit antibody, SkM1 antibody, Sodium channel protein skeletal muscle subunit alpha antibody, Sodium channel protein type 4 subunit alpha antibody, Sodium channel protein type IV subunit alpha antibody, Sodium channel voltage gated type IV alpha subunit antibody, Voltage gated sodium channel subunit alpha Nav1.4 antibody, Voltage gated sodium channel type 4 alpha antibody, Voltage-gated sodium channel subunit alpha Nav1.4 antibody

UniProt: P35499