BARD1 antibody (N-Term)

Catalog No. ABIN7184419

Product Details anti-BARD1 Antibody

Target: BARD1 (BRCA1 Associated RING Domain 1 (BARD1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BARD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from N-terminal of Human BARD1.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BARD1

Target: BARD1 (BRCA1 Associated RING Domain 1 (BARD1))

Alternative Name: BARD1 (BARD1 Products)

Synonyms: BARD1 antibody, LOC100147913 antibody, ENSMUSG00000060893 antibody, ENSMUSG00000073653 antibody, BRCA1 associated RING domain 1 antibody, BARD1 antibody, bard1 antibody, Bard1 antibody

Background:

Background: Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.

Wu L.C., Nat. Genet. 14:430-440(1996).
Thai T.H., Hum. Mol. Genet. 7:195-202(1998).
Hillier L.W., Nature 434:724-731(2005).

Aliases: BARD-1 antibody, Bard1 antibody, BARD1_HUMAN antibody, BRCA1 associated RING domain 1 antibody, BRCA1 associated RING domain gene 1 antibody, BRCA1 associated RING domain protein 1 antibody, BRCA1-associated RING domain protein 1 antibody

UniProt: Q99728

Pathways: DNA Damage Repair