HSD11B1 antibody (N-Term)

Catalog No. ABIN7184465

This Rabbit Polyclonal antibody specifically detects HSD11B1 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for HSD11B1 antibody (N-Term) (ABIN7184465)

Target: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD11B1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-HSD11B1 Antibody

Binding Specificity: N-Term

Cross-Reactivity: Human, Mouse

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from N-terminal of Human HSD11B1.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HSD11B1

Target: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Alternative Name: HSD11B1

Background:

Background: Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol By similarity.

Tannin G.M., J. Biol. Chem. 266:16653-16658(1991).
Draper N., J. Clin. Endocrinol. Metab. 87:4984-4990(2002).
Ota T., Nat. Genet. 36:40-45(2004) .

Aliases: 11 beta HSD 1 antibody, 11 beta HSD1 antibody, 11 beta hydroxysteroid dehydrogenase 1 antibody, 11 DH antibody, 11-beta hydroxysteroid dehydrogenase, type 1 antibody, 11-beta-HSD1 antibody, 11-beta-hydroxysteroid dehydrogenase 1 antibody, 11-DH antibody, 11DH antibody, Corticosteroid 11 beta dehydrogenase isozyme 1 antibody, Corticosteroid 11-beta-dehydrogenase isozyme 1 antibody, CORTRD2 antibody, DHI1_HUMAN antibody, HDL antibody, HSD 11 antibody, HSD11 antibody, HSD11B antibody, HSD11B1 antibody, HSD11L antibody, Hydroxysteroid (11 beta) dehydrogenase antibody, Hydroxysteroid (11 beta) dehydrogenase 1 antibody, MGC13539 antibody, SDR26C1 antibody, short chain dehydrogenase/reductase family 26C, member 1 antibody

UniProt: P28845

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Carbohydrate Metabolic Process