CABLES2 antibody

Catalog No. ABIN7190032

Product Details anti-CABLES2 Antibody

Target: CABLES2 (Cdk5 and Abl Enzyme Substrate 2 (CABLES2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CABLES2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of Human CABLES2

Isotype: IgG

Application Details

Application Notes: ELISA:1:1000-1:2000, IHC:1:25-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CABLES2

Target: CABLES2 (Cdk5 and Abl Enzyme Substrate 2 (CABLES2))

Alternative Name: CABLES2 (CABLES2 Products)

Synonyms: cables2 antibody, CABLES2 antibody, C20orf150 antibody, dJ908M14.2 antibody, ik3-2 antibody, Cdk5 and Abl enzyme substrate 2 antibody, CDK5 and Abl enzyme substrate 2 antibody, CABLES2 antibody, cables2 antibody, Cables2 antibody

Background:

Background: Cables2 (Cdk5 and ABL1 enzyme substrate 2), also known as Ik3-2, is a 478 amino acid ubiquitously expressed protein that has a C-terminal cyclin box-containing domain, making it a member of the cyclin protein superfamily. A related protein, Cables, forms a trimolecular complex with Cdk5 and c-Abl in vivo, enhances apoptosis induced by overexpression of p53 and may be a tumor suppressor, due to its chromosomal loss of heterozygosity that is found in certain cancers. Cables2 shares 78 % sequence similarity with Cables in the region of the cyclin box-containing domain and, in similar functionality, associates with Cdk3, Cdk5 and c-Abl. However, unlike its close relative, Cables2 also contains an N-terminal region that enhances not only p53-mediated cell death, but also p53-independent cell death. This characteristic suggests that the gene encoding Cables2 may also function as a tumor suppressor gene.

Aliases: CABLES2 antibody, C20orf150 antibody, CDK5 and ABL1 enzyme substrate 2 antibody, Interactor with CDK3 2 antibody, Ik3-2 antibody

UniProt: Q9BTV7