SRGAP1 antibody

Catalog No. ABIN7342970

Product Details anti-SRGAP1 Antibody

Target: SRGAP1 (SLIT-ROBO rho GTPase Activating Protein 1 (SRGAP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRGAP1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of Human SRGAP1

Isotype: IgG

Application Details

Application Notes: ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SRGAP1

Target: SRGAP1 (SLIT-ROBO rho GTPase Activating Protein 1 (SRGAP1))

Alternative Name: SRGAP1 (SRGAP1 Products)

Synonyms: ARHGAP13 antibody, 4930572H05Rik antibody, Arhgap13 antibody, RGD1566260 antibody, SLIT-ROBO Rho GTPase activating protein 1 antibody, SRGAP1 antibody, srgap1 antibody, Srgap1 antibody

Background:

Background: SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 µLtimately leads to a decrease in actin polymerization.

Aliases: 4930572H05Rik antibody, ARHGAP13 antibody, FLJ22166 antibody, KIAA1304 antibody, RGD1566260 antibody, Rho GTPase activating protein 13 antibody, Rho GTPase-activating protein 13 antibody, SLIT ROBO Rho GTPase activating protein 1 antibody, SLIT-ROBO Rho GTPase-activating protein 1 antibody, SRGAP 1 antibody, srGAP1 antibody, SRGP1_HUMAN antibody

UniProt: Q7Z6B7