PTPRF antibody (AA 1104-1163)

Catalog No. ABIN7193270

Product Details anti-PTPRF Antibody

Target: PTPRF (Protein Tyrosine Phosphatase Receptor Type F (PTPRF))

Binding Specificity: AA 1104-1163

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PTPRF antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (IHC), Neutralization (Neut)

Purification: purified

Immunogen: Purified recombinant fragment of human PTPRF (AA: extra 1104-1163) expressed in E. coli.

Clone: 6D7C7

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400, ICC: N/A, IHC: N/A

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for PTPRF

Target: PTPRF (Protein Tyrosine Phosphatase Receptor Type F (PTPRF))

Alternative Name: PTPRF (PTPRF Products)

Synonyms: LAR antibody, AA591035 antibody, LARS antibody, RPTP-LAR antibody, LARFN5C antibody, zf-LAR antibody, protein tyrosine phosphatase, receptor type F antibody, protein tyrosine phosphatase, receptor type, F antibody, protein tyrosine phosphatase, receptor type, f, a antibody, PTPRF antibody, Ptprf antibody, ptprfa antibody

Background:

Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Aliases: LAR, BNAH2

Molecular Weight: 213 kDa

Gene ID: 5792

Pathways: EGFR Signaling Pathway