CHAC1 antibody

Catalog No. ABIN7227870

The Rabbit Polyclonal anti-CHAC1 antibody (ABIN7227870) specifically detects CHAC1 in WB and ELISA. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for CHAC1 antibody (ABIN7227870)

Target: CHAC1 (ChaC, Cation Transport Regulator Homolog 1 (CHAC1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHAC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CHAC1 Antibody

Purpose: Rabbit Anti-CHAC1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of CHAC1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human CHAC1 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CHAC1

Target: CHAC1 (ChaC, Cation Transport Regulator Homolog 1 (CHAC1))

Alternative Name: CHAC1

Background: Glutathione-specific gamma-glutamylcyclotransferase 1, Gamma-GCG 1, Blocks Notch protein, Botch, Cation transport regulator-like protein 1CHAC1 encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of CHAC1 may indicate increased risk of cancer recurrence among breast and ovarian cancer patients.

Molecular Weight: 24kD

Gene ID: 79094

UniProt: Q9BUX1