CHAC1 antibody (AA 43-264)

Catalog No. ABIN7154130

Product Details anti-CHAC1 Antibody

Target: CHAC1 (ChaC, Cation Transport Regulator Homolog 1 (CHAC1))

Binding Specificity: AA 43-264

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHAC1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Glutathione-specific gamma-glutamylcyclotransferase 1 protein (43-264AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CHAC1

Target: CHAC1 (ChaC, Cation Transport Regulator Homolog 1 (CHAC1))

Alternative Name: CHAC1 (CHAC1 Products)

Synonyms: 1810008K03Rik antibody, RGD1307153 antibody, ChaC glutathione specific gamma-glutamylcyclotransferase 1 antibody, ChaC, cation transport regulator 1 antibody, ChaC glutathione-specific gamma-glutamylcyclotransferase 1 antibody, CHAC1 antibody, Chac1 antibody

Background:

Background: Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution (PubMed:23070364). Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).

Aliases: Blocks Notch protein antibody, Botch antibody, Cation transport regulator like protein 1 antibody, Cation transport regulator-like protein 1 antibody, ChaC antibody, ChaC cation transport regulator homolog 1 antibody, ChaC cation transport regulator like 1 antibody, chac1 antibody, CHAC1_HUMAN antibody, Gamma GCT acting on glutathione homolog 1 antibody, Gamma-GCG 1 antibody, Glutathione-specific gamma-glutamylcyclotransferase 1 antibody

UniProt: Q9BUX1