FOXO4 antibody (acLys189)

Catalog No. ABIN7228584

The Rabbit Polyclonal anti-FOXO4 antibody is suitable to detect FOXO4 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for FOXO4 antibody (acLys189) (ABIN7228584)

Target: FOXO4 (Forkhead Box O4 (FOXO4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXO4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-FOXO4 Antibody

Binding Specificity: acLys189

Purpose: Rabbit Anti-FoxO4 (Acetyl Lys189) Polyclonal Antibody

Specificity: The antibody detects endogenous levels of FoxO4 when Acetyl occurs at Lys189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human FoxO4 (Acetyl Lys189) protein at AA range: 189

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:10000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for FOXO4

Target: FOXO4 (Forkhead Box O4 (FOXO4))

Alternative Name: FoxO4

Background: Forkhead box protein O4, Fork head domain transcription factor AFX1FOXO4 encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving FOXO4 on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for FOXO4. FOXO4 (Forkhead Box O4) is a Protein Coding gene. Diseases associated with FOXO4 include Balloon Cell Malignant Melanoma and Sarcomatoid Squamous Cell Skin Carcinoma. Among its related pathways are AGE/RAGE pathway and RET signaling.

Molecular Weight: 55kD

Gene ID: 4303

UniProt: P98177

Pathways: Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation