IL12RB2 antibody (AA 270-350)

Catalog No. ABIN7228994

The Rabbit Polyclonal anti-IL12RB2 antibody (ABIN7228994) specifically detects IL12RB2 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for IL12RB2 antibody (AA 270-350) (ABIN7228994)

Target: IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL12RB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-IL12RB2 Antibody

Binding Specificity: AA 270-350

Purpose: Rabbit Anti-I12R2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of I12R2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human I12R2 protein at AA range: 270-350

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for IL12RB2

Target: IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))

Alternative Name: I12R2

Background: Interleukin-12 receptor subunit beta-2, IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, IL-12RB2The Interleukin 12 Receptor Subunit Beta 2 encoded by IL12RB2 is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.

Molecular Weight: 94kD

Gene ID: 3595

UniProt: Q99665

Pathways: JAK-STAT Signaling