LIFR antibody (Internal Region)

Catalog No. ABIN7218712

This Rabbit Polyclonal antibody specifically detects LIFR in WB, IHC and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for LIFR antibody (Internal Region) (ABIN7218712)

Target: LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LIFR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-LIFR Antibody

Binding Specificity: Internal Region

Purpose: Rabbit Anti-LIFR Polyclonal Antibody

Specificity: LIFR Polyclonal Antibody detects endogenous levels of LIFR protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human LIFR

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300,ELISA 1:2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for LIFR

Target: LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))

Alternative Name: LIFR

Background: LIFR, Leukemia inhibitory factor receptor, LIF receptor, LIF-R, CD118LIFR encodes leukemia inhibitory factor receptor alpha that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5,8)(p13,q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.

Molecular Weight: 120kD

Gene ID: 3977

UniProt: P42702

Pathways: JAK-STAT Signaling, Growth Factor Binding