Neuregulin 3 antibody (Internal Region)

Catalog No. ABIN7226724

This Rabbit Polyclonal antibody specifically detects Neuregulin 3 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for Neuregulin 3 antibody (Internal Region) (ABIN7226724)

Target: Neuregulin 3 (NRG3)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuregulin 3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Neuregulin 3 Antibody

Binding Specificity: Internal Region

Purpose: Rabbit Anti-Neuregulin-3 Polyclonal Antibody

Specificity: Neuregulin-3 Polyclonal Antibody detects endogenous levels of Neuregulin-3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Neuregulin-3

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC: 1:100-1:300,ELISA 1:10000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Neuregulin 3

Target: Neuregulin 3 (NRG3)

Alternative Name: Neuregulin-3

Background: NRG3, Pro-neuregulin-3, membrane-bound isoform, Pro-NRG3NRG3 (neuregulin 3) is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated NRG3 as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.

Molecular Weight: 80kD

Gene ID: 10718

UniProt: P56975

Pathways: RTK Signaling