Nkx2-2 antibody

Catalog No. ABIN7230018

The Rabbit Polyclonal anti-Nkx2-2 antibody is suitable to detect Nkx2-2 in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for Nkx2-2 antibody (ABIN7230018)

Target: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nkx2-2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Nkx2-2 Antibody

Purpose: Rabbit Anti-NKX22 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of NKX22 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human NKX22 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Nkx2-2

Target: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Alternative Name: NKX22

Background: Homeobox protein Nkx-2.2, Homeobox protein NK-2 homolog BNKX2-2 (NK2 Homeobox 2) is a Protein Coding gene. Diseases associated with NKX2-2 include Maturity-Onset Diabetes Of The Young and Oligodendroglioma. Among its related pathways are Regulation of beta-cell development and Dopaminergic Neurogenesis. The protein encoded by NKX2-2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. NKX2-2 is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.

Molecular Weight: 30kD

Gene ID: 4821

UniProt: O95096

Pathways: Dopaminergic Neurogenesis