PLOD2 antibody (AA 600-680)

Catalog No. ABIN7230696

The Rabbit Polyclonal anti-PLOD2 antibody (ABIN7230696) specifically detects PLOD2 in WB and ELISA. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for PLOD2 antibody (AA 600-680) (ABIN7230696)

Target: PLOD2 (Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLOD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PLOD2 Antibody

Binding Specificity: AA 600-680

Purpose: Rabbit Anti-PLOD2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of PLOD2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human PLOD2 protein at AA range: 600-680

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PLOD2

Target: PLOD2 (Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2))

Alternative Name: PLOD2

Background: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2, Lysyl hydroxylase 2, LH2The protein encoded by PLOD2 is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of PLOD2 are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 81kD

Gene ID: 5352

UniProt: O00469

Pathways: SARS-CoV-2 Protein Interactome