SYNE2 antibody (AA 360-440)

Catalog No. ABIN7231618

The Rabbit Polyclonal anti-SYNE2 antibody is suitable to detect SYNE2 in samples from Human and Mouse. It has been validated for IHC and IF.

Quick Overview for SYNE2 antibody (AA 360-440) (ABIN7231618)

Target: SYNE2 (Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYNE2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-SYNE2 Antibody

Binding Specificity: AA 360-440

Purpose: Rabbit Anti-SYNE2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of SYNE2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human SYNE2 protein at AA range: 360-440

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SYNE2

Target: SYNE2 (Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2))

Alternative Name: SYNE2

Background: Nesprin-2, KASH domain-containing protein 2, KASH2, Nuclear envelope spectrin repeat protein 2, Nucleus and actin connecting element protein, Protein NUANCE, Synaptic nuclear envelope protein 2, Syne-2SYNE2 (Spectrin Repeat Containing Nuclear Envelope Protein 2) is a Protein Coding gene. Diseases associated with SYNE2 include Emery-Dreifuss Muscular Dystrophy 5, Autosomal Dominant and Emery-Dreifuss Muscular Dystrophy 2, Ad. Among its related pathways are Meiosis and Ovarian Infertility Genes. The protein encoded by SYNE2 is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus.

Molecular Weight: 757kD

Gene ID: 23224

UniProt: Q8WXH0

Pathways: Maintenance of Protein Location