TAPBP antibody

Catalog No. ABIN7231882

The Rabbit Polyclonal anti-TAPBP antibody is suitable to detect TAPBP in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for TAPBP antibody (ABIN7231882)

Target: TAPBP (TAP Binding Protein (Tapasin) (TAPBP))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAPBP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TAPBP Antibody

Purpose: Rabbit Anti-TPSN Polyclonal Antibody

Specificity: The antibody detects endogenous levels of TPSN protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human TPSN protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TAPBP

Target: TAPBP (TAP Binding Protein (Tapasin) (TAPBP))

Alternative Name: TPSN

Background: Tapasin, TPN, TPSN, NGS-17, TAP-associated protein, TAP-binding proteinTAPBP encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. TAPBP lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.

Molecular Weight: 49kD

Gene ID: 6892

UniProt: O15533