TICAM1 antibody (AA 663-712)

Catalog No. ABIN7226884

The Rabbit Polyclonal anti-TICAM1 antibody is suitable to detect TICAM1 in samples from Human and Mouse. It has been validated for WB, IHC, ELISA and IF.

Quick Overview for TICAM1 antibody (AA 663-712) (ABIN7226884)

Target: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TICAM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-TICAM1 Antibody

Binding Specificity: AA 663-712

Purpose: Rabbit Anti-TRIF Polyclonal Antibody

Specificity: TRIF Polyclonal Antibody detects endogenous levels of TRIF.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from TRIF at AA range: 663-712

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-200,ELISA 1:10000-20000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TICAM1

Target: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Alternative Name: TRIF

Background: TIR domain-containing adapter molecule 1, TICAM-1, Proline-rich, vinculin and TIR domain-containing protein B, Putative NF-kappa-B-activating protein 502H, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta, TIR domain-containing adapter protein inducing IFN-betaTICAM1 (toll like receptor adaptor molecule 1) encodes an adaptor protein containing a Toll/interleukin-1 receptor(TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors(TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response.

Molecular Weight: 80kD

Gene ID: 148022

UniProt: Q8IUC6

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades