TANK antibody (AA 140-220)

Catalog No. ABIN7218846

The Rabbit Polyclonal anti-TANK antibody (ABIN7218846) specifically detects TANK in WB, ELISA, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for TANK antibody (AA 140-220) (ABIN7218846)

Target: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TANK antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-TANK Antibody

Binding Specificity: AA 140-220

Purpose: Rabbit Anti-TANK Polyclonal Antibody

Specificity: TANK Polyclonal Antibody detects endogenous levels of TANK protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human TANK at AA range: 140-220

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:10000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TANK

Target: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Alternative Name: TANK

Background: TANK, ITRAF, TRAF2, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, I-TRAFThe TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The TRAF family member associated NFKB activator encoded by TANK is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 48kD

Gene ID: 10010

UniProt: Q92844

Pathways: p53 Signaling, TLR Signaling, Activation of Innate immune Response