NPX1 antibody (Secreted)

Catalog No. ABIN7886699

The Rabbit Polyclonal anti-NPX1 antibody (ABIN7886699) specifically detects NPX1 in WB and IHC. The antibody is reactive with Mouse samples.

Quick Overview for NPX1 antibody (Secreted) (ABIN7886699)

Target: NPX1 (Neuronal Pentraxin 1 (NPX1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPX1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-NPX1 Antibody

Binding Specificity: AA 197-211, Secreted

Purpose: A Rabbit Polyclonal antibody to Neuronal Pentraxin 1 (NPTX1)

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Rat - identical, Human - 13 out of 15 amino acid residues identical

Characteristics: Secreted

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)ERAKIESALTSLHQR, corresponding to amino acid residues 197 - 211 of mouse NPTX1

Isotype: IgG

Application Details

Application Notes:

WB: 1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7236078)

Blocking Peptide: (ABIN7236078)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for NPX1

Target: NPX1 (Neuronal Pentraxin 1 (NPX1))

Alternative Name: NPTX1

Background:

Synonyms: Neuronal Pentraxin-1, NP1

Description: Neuronal Pentraxin 1 (NP1 or NPTX1) is a 47-50 kDa secreted glycoprotein that is expressed in the central nervous system and involved in excitatory synaptic remodeling1. The pentraxin superfamily members are made from monomers arranged in pentameric structures with a discoid shape. The family members are characterized by a 205 amino acids long conserved sequence located at C-terminal called the pentraxin domain with a shorter inner conserved sequence called the pentraxin signature 2.NP1 is preferentially expressed in the brain and is involved in glutamate receptor internalization. It is secreted pre-synaptically and implicated in excitatory synaptic and mitochondrial deficits. In addition, NP1 may represent a potential synapse-derived plasma biomarker that is able to identify alterations in excitatory synapses and early-onset Alzheimer's disease3.

Gene ID: 18164

NCBI Accession: NM_018713

UniProt: Q62443

Pathways: Carbohydrate Homeostasis, Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals, SARS-CoV-2 Protein Interactome