CRTC2 antibody (AA 434-693)

Catalog No. ABIN7266519

The Rabbit Polyclonal anti-CRTC2 antibody (ABIN7266519) specifically detects CRTC2 in WB. The antibody is reactive with Human samples.

Quick Overview for CRTC2 antibody (AA 434-693) (ABIN7266519)

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRTC2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CRTC2 Antibody

Binding Specificity: AA 434-693

Purpose: CRTC2 Rabbit pAb

Sequence: PLSLLAGPAD ARRSQQQLPK QFSPTMSPTL SSITQGVPLD TSKLSTDQRL PPYPYSSPSL VLPTQPHTPK SLQQPGLPSQ SCSVQSSGGQ PPGRQSHYGT PYPPGPSGHG QQSYHRPMSD FNLGNLEQFS MESPSASLVL DPPGFSEGPG FLGGEGPMGG PQDPHTFNHQ NLTHCSRHGS GPNIILTGDS SPGFSKEIAA ALAGVPGFEV SAAGLELGLG LEDELRMEPL GLEGLNMLSD PCALLPDPAV EESFRSDRLQ

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 434-693 of human CRTC2 (NP_859066.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CRTC2

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Alternative Name: CRTC2

Background: This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.,CRTC2,TORC-2,TORC2,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Nuclear hormone receptors,Cancer,Signal Transduction,Endocrine & Metabolism,AMPK Signaling Pathway,Neuroscience,CRTC2

Molecular Weight: 73kDa

Gene ID: 200186

UniProt: Q53ET0

Pathways: AMPK Signaling, Carbohydrate Homeostasis