ERCC2 antibody

Catalog No. ABIN7267057

This Rabbit Monoclonal antibody specifically detects ERCC2 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for ERCC2 antibody (ABIN7267057)

Target: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ERCC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ERCC2 Antibody

Purpose: XPD/ERCC2 Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant protein of human XPD/ERCC2.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ERCC2

Target: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Alternative Name: XPD

Background: The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,ERCC2, COFS2, EM9, TFIIH, TTD, TTD1, XPD, ERCC excision repair 2, TFIIH core complex helicase subunit,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cell Biology & Developmental Biology,Apoptosis,XPD

Molecular Weight: 75kDa

Gene ID: 2068

UniProt: P18074

Pathways: DNA Damage Repair