IBTK antibody (AA 900-1200)

Catalog No. ABIN7267871

The Rabbit Polyclonal anti-IBTK antibody is suitable to detect IBTK in samples from Human. It has been validated for WB.

Quick Overview for IBTK antibody (AA 900-1200) (ABIN7267871)

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IBTK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IBTK Antibody

Binding Specificity: AA 900-1200

Purpose: IBTK Rabbit pAb

Sequence: GLNMAALLEA RSLDVLSDGV LKDLSEFYRK MIPAMDRRVI TPYQDGPDIS YLEVEDGDIF LKEEINMEQN HSETMFKKAK TKAKKKPRKR SDSSGGYNLS DIIQSPSSTG LLKSGKTNSV ESLPELLTSD SEGSYAGVGS PRDLQSPDFT TGFHSDKIEA KVKPYVNGTS PVYSREDLKP WEKSPILKIS APQPIPSNRI DTTSSASWVA GSFSPVSPPV VDLRTIMEIE ESRQKCGATP KSHLGKTVSH GVKLSQKQRK MIALTTKENN SGMNSMETVL FTPSKAPKPV NAWASSLHSV S

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 900-1200 of human IBTK (NP_056340.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IBTK

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Alternative Name: IBTK

Background: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,IBTK,BTBD26,BTKI,Signal Transduction,Kinase,IBTK

Molecular Weight: 26kDa/133kDa/150kDa

Gene ID: 25998

UniProt: Q9P2D0