MMP2 antibody

Catalog No. ABIN7268428

This Rabbit Monoclonal antibody specifically detects MMP2 in WB. It exhibits reactivity toward Human.

Quick Overview for MMP2 antibody (ABIN7268428)

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MMP2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MMP2 Antibody

Purpose: MMP2 Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human MMP2

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Alternative Name: MMP2

Background: This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014],CLG4,CLG4A,MMP-2,MMP-II,MONA,TBE-1,MMP2,Angiogenesis,Cancer,Cardiovascular,Cell Biology & Developmental Biology,Endocrine & Metabolism,Extracellular Matrix,Extracellular Matrix_MMPs,G protein signaling,G protein signaling_G-Protein-Coupled Receptors Signaling to MAPK/Erk,Hypoxia,Invasion and Metastasis,Signal Transduction,Tumor biomarkers,Ubiquitin,MMP2

Molecular Weight: 72kDa

Gene ID: 4313

UniProt: P08253

Pathways: Activation of Innate immune Response