Menin antibody (AA 266-615)

Catalog No. ABIN7268698

This Rabbit Polyclonal antibody specifically detects Menin in WB. It exhibits reactivity toward Human.

Quick Overview for Menin antibody (AA 266-615) (ABIN7268698)

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Menin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Menin Antibody

Binding Specificity: AA 266-615

Purpose: Menin Rabbit pAb

Sequence: QKLLWLLYDL GHLERYPMAL GNLADLEELE PTPGRPDPLT LYHKGIASAK TYYRDEHIYP YMYLAGYHCR NRNVREALQA WADTATVIQD YNYCREDEEI YKEFFEVAND VIPNLLKEAA SLLEAGEERP GEQSQGTQSQ GSALQDPECF AHLLRFYDGI CKWEEGSPTP VLHVGWATFL VQSLGRFEGQ VRQKVRIVSR EAEAAEAEEP WGEEAREGRR RGPRRESKPE EPPPPKKPAL DKGLGTGQGA VSGPPRKPPG TVAGTARGPE GGSTAQVPAP AASPPPEGPV LTFQSEKMKG MKELLVATKI NSSAIKLQLT AQSQVQMKKQ KVSTPSDYTL SFLKRQRKGL

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 266-615 of human Menin (NP_000235.2).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Menin

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Alternative Name: MEN1

Background: This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.,MEN1,MEAI,SCG2,menin,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,MEN1

Molecular Weight: 63kDa/67kDa/68kDa

Gene ID: 4221

UniProt: O00255

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity