NLRP12 antibody (AA 862-1062)

Catalog No. ABIN7268938

This Rabbit Polyclonal antibody specifically detects NLRP12 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for NLRP12 antibody (AA 862-1062) (ABIN7268938)

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP12 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-NLRP12 Antibody

Binding Specificity: AA 862-1062

Purpose: NLRP12 Rabbit pAb

Sequence: LWLKICRLTA AACDELASTL SVNQSLRELD LSLNELGDLG VLLLCEGLRH PTCKLQTLRL GICRLGSAAC EGLSVVLQAN HNLRELDLSF NDLGDWGLWL LAEGLQHPAC RLQKLWLDSC GLTAKACENL YFTLGINQTL TDLYLTNNAL GDTGVRLLCK RLSHPGCKLR VLWLFGMDLN KMTHSRLAAL RVTKPYLDIG C

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 862-1062 of human NLRP12 (NP_001264055.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NLRP12

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Alternative Name: NLRP12

Background: This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants.,NLRP12,CLR19.3,FCAS2,NALP12,PAN6,PYPAF7,RNO,RNO2,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Caspases,NLRP12

Molecular Weight: 31kDa/101kDa/107kDa/113kDa/114kDa/120kDa

Gene ID: 91662

UniProt: P59046

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome