NSP4 antibody
Reactivity: SARS Coronavirus-2 (SARS-CoV-2)
WB
Host: Rabbit
Polyclonal
unconjugated
1 image
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- Target
- NSP4
- Reactivity
- SARS Coronavirus-2 (SARS-CoV-2)
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Western Blotting (WB)
- Purpose
- SARS-CoV-2 NSP4 Rabbit pAb
- Cross-Reactivity
- SARS Coronavirus-2 (SARS-CoV-2)
- Characteristics
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein of SARS-CoV-2 NSP4.
- Isotype
- IgG
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- Application Notes
- WB,1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- NSP4
- Target Type
- Viral Protein
- Background
- [Spike protein S1]: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein. Binding to host NRP1 and NRP2 via C-terminal polybasic sequence enhances virion entry into host cell. This interaction may explain virus tropism of human olfactory epithelium cells, which express high level of NRP1 and NRP2 but low level of ACE2. The stalk domain of S contains three hinges, giving the head unexpected orientational freedom. Uses human TMPRSS2 for priming in human lung cells which is an essential step for viral entry. Can be alternatively processed by host furin. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.,NSP4
- Gene ID
- 43740578
- UniProt
- P0DTD1
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