PACSIN1 antibody (AA 240-390)

Catalog No. ABIN7269626

Product Details anti-PACSIN1 Antibody

Target: PACSIN1 (Protein Kinase C and Casein Kinase Substrate in Neurons 1 (PACSIN1))

Binding Specificity: AA 240-390

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PACSIN1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: PACSIN1 Rabbit pAb

Sequence: KRLVFLKEVL LDIKRHLNLA ENSSYIHVYR ELEQAIRGAD AQEDLRWFRS TSGPGMPMNW PQFEEWNPDL PHTTTKKEKQ PKKAEGVALT NATGAVESTS QAGDRGSVSS YDRGQPYATE WSDDESGNPF GGSETNGGAN PFEDDSKGVR V

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 240-390 of human PACSIN1 (NP_065855.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PACSIN1

Target: PACSIN1 (Protein Kinase C and Casein Kinase Substrate in Neurons 1 (PACSIN1))

Alternative Name: PACSIN1 (PACSIN1 Products)

Synonyms: MGC84055 antibody, sdpii antibody, pacsin1 antibody, x-PACSIN2 antibody, fe25d06 antibody, wu:fe25d06 antibody, zgc:114042 antibody, PACSIN1 antibody, SDPI antibody, A830061D09Rik antibody, H74 antibody, mKIAA1379 antibody, syndapin antibody, protein kinase C and casein kinase substrate in neurons 1 antibody, protein kinase C and casein kinase substrate in neurons 1 S homeolog antibody, protein kinase C and casein kinase substrate in neurons 2 antibody, protein kinase C and casein kinase substrate in neurons 1b antibody, PACSIN1 antibody, pacsin1.S antibody, pacsin2 antibody, pacsin1b antibody, Pacsin1 antibody

Background: Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT, this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis, this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity. Binds to membranes via its F-BAR domain and mediates membrane tubulation.,PACSIN1,SDPI,Signal Transduction,PACSIN1

Molecular Weight: 50kDa

Gene ID: 29993

UniProt: Q9BY11