UQCRFS1 antibody

Catalog No. ABIN7271127

Product Details anti-UQCRFS1 Antibody

Target: UQCRFS1 (Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1 (UQCRFS1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This UQCRFS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purpose: UQCRFS1 Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human UQCRFS1

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for UQCRFS1

Target: UQCRFS1 (Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1 (UQCRFS1))

Alternative Name: UQCRFS1 (UQCRFS1 Products)

Synonyms: uqcrfs1 antibody, MGC53134 antibody, rip1 antibody, ris1 antibody, risp antibody, uqcr5 antibody, fb78f10 antibody, wu:fb05d11 antibody, wu:fb78f10 antibody, wu:fj05e12 antibody, zgc:73109 antibody, zgc:85614 antibody, GLEAN_00043 antibody, RIP1 antibody, RIS1 antibody, RISP antibody, UQCR5 antibody, 4430402G14Rik antibody, AI875505 antibody, LRRGT00195 antibody, UQCRFSL1 antibody, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 S homeolog antibody, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 antibody, cytochrome b-c1 complex subunit Rieske, mitochondrial antibody, iron-sulfur protein 1 antibody, uqcrfs1.S antibody, uqcrfs1 antibody, LOC661125 antibody, LOC705178 antibody, UQCRFS1 antibody, Uqcrfs1 antibody, LOC100227575 antibody, isp1 antibody

Background: [Cytochrome b-c1 complex subunit Rieske, mitochondrial]: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII, ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII and cytochrome c oxidase (complex IV, CIV, that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0 site in cytochrome b to cytochrome c1 (By similarity. Incorporation of UQCRFS1 is the penultimate step in complex III assembly.,RIP1, RIS1, RISP, UQCR5,Cancer,Cell Biology & Developmental Biology,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial metabolism_Mitochondrial markers,Mitochondrial metabolism_Oxidative phosphorylation,Neurodegenerative Diseases,Neuroscience,Signal Transduction,UQCRFS1

Molecular Weight: 23kDa

Gene ID: 7386

UniProt: P47985

Pathways: Proton Transport