UHRF1 antibody (meLys385)

Catalog No. ABIN7271189

The Rabbit Polyclonal anti-UHRF1 antibody has been validated for WB, IHC and DB. It is suitable to detect UHRF1 in samples from Human.

Quick Overview for UHRF1 antibody (meLys385) (ABIN7271189)

Target: UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UHRF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Dot Blot (DB)

Product Details anti-UHRF1 Antibody

Binding Specificity: meLys385

Purpose: MonoMethyl-UHRF1-K385 Rabbit pAb

Sequence: KAKMA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Methylated Antibodies

Purification: Affinity purification

Immunogen: A synthetic monomethylated peptide around K385 of human UHRF1 (NP_001041666.1).

Isotype: IgG

Application Details

Application Notes: DB,1:500 - 1:2000,WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for UHRF1

Target: UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))

Alternative Name: UHRF1

Background: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.,UHRF1,ICBP90,Np95,RNF106,TDRD22,hNP95,hUHRF1,huNp95,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Apoptosis,UHRF1

Molecular Weight: 89kDa/91kDa

Gene ID: 29128

UniProt: Q96T88