PERK antibody

Catalog No. ABIN7384367

This Rabbit Monoclonal antibody specifically detects PERK in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PERK antibody (ABIN7384367)

Target: PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PERK antibody is un-conjugated

Application: Western Blotting (WB)

Clone: R09-1F9

Product Details anti-PERK Antibody

Purification: Affinity Purified

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000

Restrictions: For Research Use only

Handling

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PERK

Target: PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))

Alternative Name: PERK

Background: DKFZp781H1925,E2AK3,EC 2.7.11.1,Eif2ak3,Eukaryotic translation initiation factor 2 alpha kinase 3,Eukaryotic translation initiation factor 2-alpha kinase 3,Heme regulated EIF2 alpha kinase,HRI,HsPEK,Pancreatic eIF2 alpha kinase,Pancreatic eIF2-alpha kinase,PEK,PRKR like endoplasmic reticulum kinase,PRKR-like endoplasmic reticulum kinase,WRS,The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. 

Molecular Weight:

Observed_MW: 140kDa

Calculated_MW: 125kDa

Gene ID: 9451

UniProt: Q9NZJ5

Pathways: Hormone Transport, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response