BRAF antibody (AA 25-75)

Catalog No. ABIN7448439

This anti-BRAF antibody is a Rabbit Polyclonal antibody detecting BRAF in IHC. Suitable for Human.

Quick Overview for BRAF antibody (AA 25-75) (ABIN7448439)

Target: BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRAF antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-BRAF Antibody

Binding Specificity: AA 25-75

Purpose: Rabbit anti-BRAF IHC Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,Bovine,Dog,Gorilla,Chimpanzee,Crab-eating macaque,White-tufted-ear marmoset,Northern white-cheeked gibbon,Small-eared galago

Purification: Affinity Purified

Immunogen: Between AA 25 and 75

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 100 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for BRAF

Target: BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))

Alternative Name: BRAF

Background: Background: B-Raf proto-oncogene serine/threonine-protein kinase (BRAF) is a member of the raf/mil family of serine/threonine kinases. BRAF is involved in transducing mitogenic signals via the MAP kinase/ERKs signaling pathway. Mutations in BRAF are involved in a wide range of cancers such as lung, non-Hodgkin lymphoma, and colorectal cancer. Defects in BRAF are also the cause of cardiofaciocutaneous syndrome (CFC), an autosomal dominant syndrome characterized by facial anomalies, heart defects, and ectodermal abnormalities.

Gene ID: 673

NCBI Accession: NP_004324

UniProt: P15056

Pathways: MAPK Signaling, RTK Signaling, Neurotrophin Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Hepatitis C, Autophagy