CHEK1 antibody (AA 250-300)

Catalog No. ABIN7448476

This Rabbit Polyclonal antibody specifically detects CHEK1 in IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for CHEK1 antibody (AA 250-300) (ABIN7448476)

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHEK1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-CHEK1 Antibody

Binding Specificity: AA 250-300

Purpose: Rabbit anti-Chk1 IHC Antibody, Affinity Purified

Predicted Reactivity: Dog,Pig,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,Small-eared galago,Northern white-cheeked gibbon

Purification: Affinity Purified

Immunogen: Between AA 250 and 300

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 100 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CHEK1

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Alternative Name: Chk1

Background: Background: Chk1 functions as a checkpoint protein kinase that is critical to the regulation of the Cdc25a and Cdc25c phosphatases that promote S and G2/M phase progression, respectively. Chk1 kinase activity inhibits cell cycle progression in the presence of DNA damage by phosphorylating Cdc25a and Cdc25c and causing the degradation of Cdc25a and cytoplasmic sequestration of Cdc25c.

Gene ID: 1111

NCBI Accession: NP_001265

UniProt: O14757

Pathways: p53 Signaling, Apoptosis, Cell Division Cycle, DNA Damage Repair