MDC1 antibody (AA 1375-1425)

Catalog No. ABIN7448658

The Rabbit Polyclonal anti-MDC1 antibody (ABIN7448658) specifically detects MDC1 in IHC. The antibody is reactive with Human samples.

Quick Overview for MDC1 antibody (AA 1375-1425) (ABIN7448658)

Target: MDC1 (Mdc1 (MDC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MDC1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-MDC1 Antibody

Binding Specificity: AA 1375-1425

Purpose: Rabbit anti-MDC1 IHC Antibody, Affinity Purified

Predicted Reactivity: Chimpanzee

Purification: Affinity Purified

Immunogen: Between AA 1375 and 1425

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for MDC1

Target: MDC1 (Mdc1 (MDC1))

Alternative Name: MDC1

Background: Background: Mediator of DNA damage checkpoint protein 1 (Mdc1) is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It may serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. It is also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis [taken from the Universal Protein Resource (UniProt) Q5PSV9].

Gene ID: 9656

NCBI Accession: NP_055456

UniProt: Q14676