Topoisomerase II alpha antibody (C-Term)

Catalog No. ABIN7448837

The Rabbit Polyclonal anti-Topoisomerase II alpha antibody is suitable to detect Topoisomerase II alpha in samples from Human. It has been validated for IHC.

Quick Overview for Topoisomerase II alpha antibody (C-Term) (ABIN7448837)

Target: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Topoisomerase II alpha antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-Topoisomerase II alpha Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-Topo II Alpha IHC Antibody, Affinity Purified

Predicted Reactivity: Orangutan,Monkey,Gorilla,Chimpanzee,Crab-eating macaque,Northern white-cheeked gibbon

Purification: Affinity Purified

Immunogen: Between AA 1500 and C-term

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Topoisomerase II alpha

Target: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Alternative Name: Topo II Alpha

Background: Background: Topoisomerases regulate topological states of DNA and are divided into type I and type II enzymes. Type II topoisomerases make double stranded breaks in DNA and allow the passage of another duplex DNA across the break to achieve unknotting of entangled DNA. Topo II Alpha is one of two described isoforms that are likely products of a gene duplication event. TopoII Alpha is also described to be involved in chromosome condensation, chromatid separation, and the relief of supercoil stress.

Gene ID: 7153

NCBI Accession: NP_001058

UniProt: P11388

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases