NLRP2 antibody (AA 704-754)

Catalog No. ABIN7448989

This Rabbit Polyclonal antibody specifically detects NLRP2 in IHC and IF (p). It exhibits reactivity toward Human.

Quick Overview for NLRP2 antibody (AA 704-754) (ABIN7448989)

Target: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-NLRP2 Antibody

Binding Specificity: AA 704-754

Purpose: Rabbit anti-NBS1 IHC Antibody, affinity purified

Predicted Reactivity: Orangutan,Monkey,Gorilla,Chimpanzee,Olive baboon,Crab-eating macaque,Bornean orangutan,Primates,Angolan talapoin,Francois's leaf monkey,Northern white-cheeked gibbon,Agile gibbon,Siamang,Black-and-white colobus monkey

Purification: Affinity Purified

Immunogen: Between AA 704 and 754

Isotype: IgG

Application Details

Application Notes:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for NLRP2

Target: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Alternative Name: NBS1

Background: Background: Mutations in NBS1 (Nijmegen Breakage Syndrome 1), also known as nibrin, are associated with the autosomal recessive syndrome, Nijmegen breakage syndrome, characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. At the cellular level, NBS1 is part of the MRE11/RAD50 double-strand break repair complex that is critical to the DNA damage response, DNA recombination, telomere integrity, and cell cycle checkpoint control.

Gene ID: 4683

NCBI Accession: NP_002476

UniProt: O60934

Pathways: Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome