PPARG antibody (AA 50-100)

Catalog No. ABIN7449902

The Rabbit Polyclonal anti-PPARG antibody has been validated for WB and IP. It is suitable to detect PPARG in samples from Human and Mouse.

Quick Overview for PPARG antibody (AA 50-100) (ABIN7449902)

Target: PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPARG antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-PPARG Antibody

Binding Specificity: AA 50-100

Purpose: Rabbit anti-PPAR-gamma Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 50 and 100

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:10,000 - 1:25,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PPARG

Target: PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))

Alternative Name: PPAR-gamma

Background: Background: PPAR-gamma is a nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. PPAR-gamma is a key regulator of adipocyte differentiation and glucose homeostasis and acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses [taken from the Universal Protein Resource (UniProt) P37231].

Gene ID: 5468

NCBI Accession: NP_056953

UniProt: P37231

Pathways: MAPK Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation