PTPN2 antibody (AA 350-400)

Catalog No. ABIN7451318

The Rabbit Polyclonal anti-PTPN2 antibody is suitable to detect PTPN2 in samples from Human. It has been validated for IP.

Quick Overview for PTPN2 antibody (AA 350-400) (ABIN7451318)

Target: PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN2 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-PTPN2 Antibody

Binding Specificity: AA 350-400

Purpose: Rabbit anti-PTPN2/TCPTP Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat

Purification: Affinity Purified

Immunogen: Between AA 350 and 400

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. Use rabbit anti-PTPN2/TCPTP antibody ABIN7451019.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PTPN2

Target: PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))

Alternative Name: PTPN2/TCPTP

Background: Background: The gene PTPN2, also known as TCPTP or TCP-TP, encodes for the protein tyrosine phosphatase (PTP) family member, tyrosine-protein phosphatase non-receptor type 2. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN2 dephosphorylates both receptor and non-receptor protein tyrosine kinases. PTPN2/TCPTP negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis [taken from NCBI Entrez Gene (Gene ID: 5771) and UniProtKB (Entry: P17706)].

Gene ID: 5771

UniProt: P17706

Pathways: EGFR Signaling Pathway, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling